Kirk J McManus Selected Research

Proteins (Proteins, Gene)

1/2024	PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat Cancer.
1/2022	DREAM, a possible answer to the estrogen paradox of the Women's Health Initiative Trial.
1/2022	Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability.
12/2021	A Comprehensive Assessment of Genetic and Epigenetic Alterations Identifies Frequent Variations Impacting Six Prototypic SCF Complex Members.
1/2021	Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches.
2/2020	Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover.
9/2015	Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells.
3/2009	Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

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Kirk J McManus Research Topics

Disease

23	Neoplasms (Cancer) 01/2024 - 03/2009
10	Chromosomal Instability (Chromosome Stability) 11/2022 - 01/2013
9	Genomic Instability 01/2022 - 07/2008
8	Carcinogenesis 01/2022 - 08/2011
4	Colorectal Neoplasms (Colorectal Cancer) 07/2019 - 01/2013
2	Carcinoma (Carcinomatosis) 11/2023 - 01/2021
2	Neoplasm Metastasis (Metastasis) 07/2023 - 03/2023
2	Aneuploidy (Aneuploid) 01/2021 - 08/2011
1	Brain Neoplasms (Brain Tumor) 07/2023
1	Ovarian Neoplasms (Ovarian Cancer) 11/2022
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Retinoblastoma (Glioblastoma, Retinal) 01/2022
1	Ovarian Epithelial Carcinoma 01/2021
1	Disease Progression 01/2021
1	Polyps 01/2018
1	Microsatellite Instability 01/2018
1	Fibrosarcoma 01/2015
1	Hypersensitivity (Allergy) 08/2011

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2024 - 03/2009
5	Histones (Histone)IBA 01/2019 - 07/2008
3	Calcibiotic Root Canal SealerIBA 11/2022 - 01/2018
3	DNA (Deoxyribonucleic Acid)IBA 11/2022 - 09/2015
2	Oncogene Proteins (Oncogene Protein)IBA 01/2024 - 12/2021
2	Biomarkers (Surrogate Marker)IBA 11/2023 - 03/2023
2	Deubiquitinating EnzymesIBA 11/2022 - 03/2021
2	F-Box ProteinsIBA 01/2022 - 08/2021
2	ChromatinIBA 03/2021 - 12/2013
2	Lysine (L-Lysine)FDA Link 02/2015 - 07/2008
1	snake venom protein C activatorIBA 04/2024
1	Proteolysis Targeting ChimeraIBA 01/2024
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2023
1	Neurofibromin 1 (Neurofibromin)IBA 11/2023
1	Epidermal Growth Factor (EGF)IBA 07/2023
1	Oral ContraceptivesIBA 11/2022
1	Ligases (Synthetase)IBA 11/2022
1	UbiquitinIBA 11/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2022
1	Estrogens (Estrogen)FDA Link 01/2022
1	Estrogen ReceptorsIBA 01/2022
1	Messenger RNA (mRNA)IBA 12/2021
1	Transcription Factors (Transcription Factor)IBA 12/2021
1	PlatinumIBA 01/2021
1	CyclinsIBA 02/2020
1	condensin complexes (condensin)IBA 07/2019
1	Ubiquitin-Specific ProteasesIBA 12/2017
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2015
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 02/2015
1	fluorescent protein 583IBA 01/2015
1	NucleotidesIBA 01/2014
1	Superoxide Dismutase-1IBA 11/2013
1	Complement System Proteins (Complement)IBA 08/2013
1	Small Interfering RNA (siRNA)IBA 01/2013
1	Flap EndonucleasesIBA 01/2013
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 08/2011
1	Nonsense Codon (Nonsense Mutation)IBA 08/2011

Therapy/Procedure

5	Precision Medicine 01/2024 - 06/2013
5	Therapeutics 07/2023 - 11/2017
3	Drug Therapy (Chemotherapy) 01/2021 - 12/2016
1	Radiotherapy 07/2023
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 01/2022